$Moderna, Inc.(MRNA)$  $Moderna, Inc.(MRNA)$  $Merck(MRK)$ Morgan Stanley's ESMO takeaways go beyond just a positive melanoma trial. The independent discussant compared INT's RFS hazard ratio with adjuvant Herceptin's. Some physicians expressed confidence that the recurrence benefit would translate into longer overall survival. A KOL argued the effect was too large to be explained solely by general immune stimulation. Manufacturing turnaround is reportedly down to 30–40 days. RCC and bladder Phase 2 trials could have registrational potential, depending on results. More than a melanoma story: growing scientific confidence in a broader oncology platform.

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