$Moderna, Inc.(MRNA)$’s market value changed by tens of billions of dollars on August 19 after its personalised cancer vaccine succeeded in a pivotal melanoma trial. The result is scientifically and strategically important, but the 177% one-day share-price gain moved faster than the available clinical and commercial detail. Moderna and Merck announced before the August 19 market open that the Phase 3 INTerpath-001 trial met its primary endpoint of recurrence-free survival and a key secondary endpoint measuring freedom from distant metastasis. The study enrolled 1,137 patients with surgically removed stage IIB–IV melanoma and compared Merck’s Keytruda plus Moderna’s intismeran with Keytruda alone. The companies described the improvements as statist
Moderna Doubles in a Day on mRNA Cancer Vaccine Data — Still Chaseable?
Moderna +176.97% to $174.38; Merck +12.60%. Their personalized mRNA cancer vaccine intismeran autogene plus Keytruda hit both survival endpoints in the Phase 3 INTerpath-001 melanoma trial — the platform's first Phase 3 oncology win. BofA took its target to $170 from $40, yet the 23-analyst consensus is still Hold at $78.78, most models unrevised. Shorts lost an estimated $4.8bn. Against that: full data unpublished, LTM revenue $2.23bn and falling 27.6%. Chase the platform, buy Merck for the royalty, or wait for the data?
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